The Tokyo Ginza Wellness & Ageing Clinic (Location: Chuo-ku, Tokyo; Director: Takahiro Otani) has started a new programme to assess the effects of multiple doses of nicotinamide mononucleotide (NMN) administered intravenously every few days.
Our clinic aims to “treat aging” through various approaches, including the use of NMN. Recently, we have established a methodology to use nicotinamide adenine dinucleotide (NAD), which decreases with age and has been suggested to be involved in the mechanisms of various aging phenomena, as a marker of aging severity, and are using it in actual practice (1).
Clinical studies conducted at the University of Tokyo have shown that NMN intake tends to improve motor functions such as walking speed and grip strength, as well as hearing (2). In addition, animal experiments using mice and other animals have reported that NMN intake reduces various aging-related phenomena such as obesity, diabetes, fatty liver, hyperlipidemia, decreased muscle metabolic capacity, decreased bone density, and decreased activity level.
In animal experiments on NMN, there have been many reports of NMN directly administered into the body by injection and its anti-aging effects observed. However, most clinical studies on humans have been conducted using oral administration, and only a single dose of intravenous administration has been used to confirm safety.
In this study, 20 healthy adult male and female subjects will receive multiple infusions of NMN every few days. Hematological and blood biochemical tests will be performed to confirm the safety of NMN infusion. In addition, we will explore the effects of NMN infusion by using aging markers that have been suggested to be related to aging, such as NAD levels and mitochondrial levels (3) before and after NMN infusion, as well as subjective evaluation by the subjects.
This clinical study will use NMN from MiraiLabo Bioscience, Inc. NMN from MiraiLabo Biosciences, Inc. has been used in clinical research funded by the U.S. Department of Defense at the University of Washington School of Medicine (4), where its quality and other characteristics have been highly evaluated.
Through this research, we hope to expand the use of NMN and explore further possibilities of NMN, thereby contributing to the extension of healthy life expectancy in a super-aging society as well as to the future development of medicine and medical science.
【Where information on this clinical research will be made publicly available】
Clinical Trial Registration (umin.ac.jp)
URL：https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000055940
【Footnote】
(1) https://www.atpress.ne.jp/news/307241
(2) https://pubmed.ncbi.nlm.nih.gov/35927255/
(3) https://prtimes.jp/main/html/rd/p/000000005.000103030.html
(4) https://www.mirailab-bio.com/nmn
【Inquiries about this matter】
Tokyo Ginza Wellness & Ageing Clinic
URL：https://tgwaclinic.com/
